Efficiency of curcuminoids against COVID-19 proteins and human ACE-2 receptor: A molecular docking study

COVID-19 is a deadly disease which has become a global issue in the recent years. At present, the whole world is trying to combat the disease and scientific communities are putting rigorous efforts in developing 100 per cent effective treatment. Though some synthetic drugs are eff icient in controlling the COVID-19, they possess numerous side effects on human body. In these consequences, there is a global need to search for the natural agents that can act against COVID-19 as a precautionary measure which can improve our immunity and also to control the COVID-19 at various stages of infection. Curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) are naturally derived plant compounds from turmeric rhizomes and are having the ability to f ight against COVID-19. Earlier studies have focused on docking of curcuminoids against spike protein and main protease of COVID-19. In the present study, docking of curcuminoids against four COVID-19 proteins and one human receptor has been studied. The efficiency of curcuminoids was compared with that of synthetic drugs. Results clearly showed the potentiality of curcuminoids against COVID-19 and can be used as an alternative to the existing synthetic drugs after sufficient clinical trials. Copyright © 2022, Indian journals. All rights reserved.

Diabetic foot disease in COVID 19 patients-a prospective study

INTRODUCTION: These are unprecedented times, where a global pandemic disrupts all aspects of local clinical practice. Yet, providing care for people with diabetic foot disease remains crucial: as clinicians caring for these patients, during peak of covid 19 many branches of medicine have adapted to telemedicine, this is difficult and challenging for the diabetic foot which often requires "hands on" treatment. METHODOLOGY: All the diabetic foot disease cases treated in various tertiary care medical colleges during covid period 1March2020 to 31 August 2021 admitted with RTPCR covid positive are taken for study. RESULTS : Total number of covid positive patients admitted and treated are 29,170 of them 9421 are DIABETIC, 143 had diabetic foot disease 7 patients undergone Below Knee AMPUTATION 19-PATIENTS NEED AMPUTAION OF DIGITS, 117 NEED DEEP DEBRIDEMENT, no mortality due to covid19, diabetic foot patients, but delayed wound healing, infections, AND INTENSIVE CARE ADMISSIONS ARE MORE COMPARED TO OTHER PATIENTS. CONCLUSION: There is no doubt that the covid-19 experience when handling diabetic foot problems will likely transform our approach to the management of diabetic foot disease especially in the areas of digital health and smart technology.double care, vaccination, mask, social distancing frequent soapand water hand wash all are necessary with adquate diabetic control. patient education plays a major role, daily mirror examination of feet and any ulcer, blister even painless should be attended immediately in order to prevent the vicious cycle of sepsis-uncontrolled DIABETES.

Laboratory abnormalities in children with COVID-19 infection in tertiary care centre,tamilnadu

Background: There is a world wide spread of Corona virus disease (COVID-19) from Wuhan city of China .It was declared as pandemic by the World Health organisation. Its spectrum of disease varies in each person. Particularly in children most of the children were asymptomatic, followed by moderate and <1% were in severe developing MIS syndrome which results in increase in inflammatory disorders. Mortality is low in the children. Not much cases reported in paediatric cases Aim of the study :The objective of the study is to describe the laboratory parameters in Covid 19 positive paediatric cases. Methodology: This study was done in Government ESIC Medical College and Hospital, Coimbatore, Tamil Nadu in Paediatric Department., from the period of May 2020 to April 2021. All the Covid positive children of age groups <12 years of both sexes were included. Patients having Non Covid Pneumonia were excluded. After getting ethical committee clearance data was collected using patient information sheet and laboratory investigations were done. The data was entered in MS excel and analysis was done using SPSS 23 Results: Majority of the study population 40% belongs to 5-10 years of age. Male predominance was noted in the study participants. Most of the children were asymptomatic 92%(700) and among the symptomatic 8%(100) the most common symptom is Fever and respiratory symptom like cold and cough. The laboratory parameter were observed to be in normal range. No elevation noted in the parameters.

Clinical profile of paediatric COVID-19 cases in a tertiary care centre

Background: In December 2019 an outbreak of novel coronavirus, Severe acute respiratory syndrome coronavirus 2(SARS CoV-2) took place in Hubei province of wuhan in china. There is a rapid spread to all the countries.In September 2020 around 1 million death were reported globally. Covid 19 in children were reported in few countries like,China, USA and Iran. There presentation was similar but severity differs.In children mostly there is a wide spectrum of clinical presentation from common cold to death. But mostly mild symptoms were noted. Very few get into severe MIS-C syndrome with elevated markers.T Aim of the study: The objective of the study is to describe the Clinical profile and Haematological Parameters in Covid 19 positive paediatric cases. Methodology: This study was done in Government ESIC Medical College and Hospital,Coimbatore, Tamil Nadu in Paediatric Department., from the period of May 2020 to April 2021. All the Covid positive children of age groups<12 years of both sexes were included. Patients having Non Covid Pneumonia were excluded. After getting ethical committee clearance data was collected using patient information sheetand laboratory investigations were done. The data was entered in MS excel and analysis was done using SPSS 23.p value <0.05 is considered significant.

Surgical emergencies in COVID - 19 in tertiary care hospitals

Introduction: The coronavirus disease 2019 (covid-19) pandemic has had a substantial effect on surgeons and patients who require surgical care. providing care for patients with surgical disease requires a unique and intimate relationship between the patient and surgeon, and this interaction and contact cannot be replaced by telehealth. as such, the surgical workforce has faced distinct challenges compared with nonsurgical specialties during the covid-19 pandemic. specific issues include the best approach to protect health care personnel and the patient;the ability to efficiently regulate delivery of surgical care;the detrimental effects on patients with surgical disease;the financial implications of the pandemic on health care systems;the management of surgical workforce shortages;the implications for education, research, and career development;and the emotional toll to all involved. Aim of study :to find out the incidence, complications, and out come of patients presented with surgical emergencies with covid-19 Methodology: All the covid positive patients confirmed by RTPCR presented with acute surgical emergency including LSCS are taken for study the study period is between march2019 to august2021 in various medical college hospitals, are taken for study. Results : Of the 25,609 patients admitted in the hospital with covid 19 required 338 lscs, 43, first trimester abortions,31 required emergency laporatomy(acute intestinal abstuction7,obstucted, strangulated ingunal hernia 9 acute appendicitis 15,) 143 diabetic foot disease.

Vaccination and COVID -19 - a prospective study

INTRODUCTION: The vaccination protects the individuals is beyond doubt, but many patients become positive even after vaccination and get admitted in hospitals. we want to study in detail the morbidity and mortality in these patients group, in a covid specialty designated hospital which admitted more than 27600 patients and taken 7,89,540 RTPCR samples, and 24,700 C.T.scans as pregnant mothers and children are excluded in order to prevent radiation hazards METHODOLOGY: All the patients admitted during the month of August and September 2021 in corona ward of government medical college and ESI hospital, Coimbatore, are taken for study. RESULTS: Total number of patients admitted are 1966, In non vaccinated admissions in covid ward 972 (49%) covid I.C.U admissions 308(16%) death 92 (4.6%) After first dose of vaccination, 612 (31%) patients required Admission in covid ward, 95(5%) required covid I.C.U beds and 20(1%) deaths . After second dose total admissions are admitted in covid ward 382, (19.4%) covid I.C.U admissions 42(2%) and death 5(0.25%) CONCLUSION: The death rate and hospital I.C.U admission are significantly reduced in patients with vaccination when compared with non vaccinated persons.

Diabetes mellitus and COVID-19: a prospective study

INTRODUCTION: Diabetes mellitus is a well-known risk factor for worse clinical outcomes in patients with Corona virus disease(COVID-19). Aim of study: To study, the out come in patients with diabetes mellitus, with RTPCR positive COVID-19 CONCLUSION: diabetic patients have the same percentage METHODOLOGY: All the patients admitted during the month of August and September 2021 in corona ward of government medical colleges, are taken for study RESULTS: Total number of patients admitted in covid ward are 1966, diabetes 246(12.5%) In non vaccinated: Total admissions 972(diabetes 124) 12.7%I.C.U admissions;308 (diabetes 38)12.3% Death;92 (diabetes 33) 35% . After first dose of vaccination,: Admissions: 612(diabetes 79)12.9% I.C.U admission, 95(diabetes 18) 18.9% deaths 20(diabetes 6) 30%. After second dose;Total admissions 382(diabetes 43)11.2% I.C.U admissions 42(diabetes 8) 19% and death 5(diabetes 2) 40% in patient admission but ICU admissions, prolonged hospital stay and death significantly more in diabetic patients. The death rate and hospital I.C.U admission is significantly reduced in patients with vaccination when compared with non vaccinated persons.

Study of cytokine storm and high dose lipososomal VIT-C in COVID-19

Introduction: Cytokine storm refers to a group of medical conditions in which the immune system is producing too many inflammatory signals, leading to multiple organ failure and death.. The recent outbreak of Covid19 requires urgent treatments for numerous patients. No suitable antivirals are available for Covid19. The efficiency against Covid19 two anti virals developed for other pathologies, is controversial. Therefore, alternative approaches are required. Intravenous (IV) Vitamin C (Vit-C) or high dose liposomal vitamin c orally has emerged as one of the other alternatives for this purpose Material and methodology: 150 patients with RTPCR Confirmed covid 19 positive without co morbidity with elevated inflammatory cytokines on admission (CRP & FERRITIN) are taken for study. After getting informed consent they were given high dose oral(2 grams) liposomal vitamin C for all, after fifth day and after tenth day the repeat tests were done in the same lab and the results are analyzed.

Role of vitamin C in reducing morbidity in patients with COVID-19

INTRODUCTION: It is not the corona virus that kills people with COVID;it is usually the immune system over-reacting against dead virus particles, which triggers a "cytokine storm, " an inflammatory fire out of control. That's when very high doses of both steroids and vitamin C are needed. Normally, the adrenal glands, which contain a hundred times more vitamin C than other organs, release both the body's most powerful steroid hormone cortisol as well as vitamin C, when in a state of emergency. The steroid helps the vitamin C get inside cells and calm down the fire. Vitamin C is both an anti-inflammatory and anti-oxidant, mopping up the "oxidant" fumes of the cytokine storm. Without vitamin C the steroid hormone cortisol can't work so well. That's why ICU doctors administer both extra vitamin C and steroids to get a patient out of the danger zone. AIM OF STUDY: To find out the role of high dose oral liposomal vitamin-c in reducing morbidity,(symptomatic relief in physical, neuro cognitive functions improvement, anxiety and depression) in patients admitted in a tertiary care covid 19 hospital between 1st march to 31 may 2021. MATERIALS AND METHODS: All the patients admitted in between march 1 to may 31 2021 are taken for study irrespective of any comorbidities. Totally 57,769 covid-19 positive persons are screened. Their RTPCR status, ct scan scores, bio chemical markers all studied, and those who were eligible for admission as per ICMR guidelines admitted(n=8634). All the patients during their entire stay in the hospital were given oral liposomal vitamin c with bio availability 90-95% in a palatable juice form apart from standard treatment protocol for covid-19 prescribed by world health organization and ICMR, AIIMS, AND GOVERNMENT OF TAMILNADU. RESULTS: Of the 8634 patients admitted 5422(62%) required non oxygen beds. -2989(34%) required oxygen beds on admission -223 patients(2.5%) required beds (with,98 on c pap,34 ventilators,64 high flow nasal oxygen, 43 non re-breathing mask and 58 non invasive ventilators), all outcomes are compared with same type of patients admitted in similar hospital and similar set of patients, were 49% required non oxygen bed,42% required oxygen beds 7.8% (9-13%)required ICU admissions and with out high dose vitamin c same type of protocol and the results compared and found out the morbidity, and is two third less in patients receiving high dose oral liposomal vitamin -C 4 grams per day. CONCLUSION: with available standard treatment protocols, addition of high dose oral vitamin c reduces morbidity by two third which is very significant in covid pandemic. It's especially important to understand that no supplement, diet, or other modification other than social distancing, wearing mask properly, and proper hygiene practices can prevent you from COVID-19.

Role of high dose oral liposomal vitamin -C in reducing mortality in patients with COVID-19

Introduction: Severe cases of COVID-19 are associated with hypoxemic respiratory failure, acute respiratory distress syndrome (ARDS), septic shock, cardiac dysfunction, elevation in multiple inflammatory cytokines, thrombo embolic disease, and/or exacerbation of underlying co morbidities. In addition to pulmonary disease, patients with COVID-19 may also experience cardiac, hepatic, renal, and central nervous system disease. AIM OF THE STUDY;To describe the role and outcome, of high-dose of oral liposomal vitamin C treatment in reducing mortality in Covid-19 patients admitted in Government Medical College & ESI Hospital, Coimbatore, India. Materials and methods: Patients who admitted with the diagnosis of COVID-19 by RTPCR in government medical college and ESI hospital Coimbatore during 1 th march 2021 to may 31,2021 are taken for this retrospective study. Of the 8634 patients admitted 5422(62%) required non oxygen beds. -2989(34%) required oxygen beds on admission -223 patients(2.5%) required beds (with,98 on c pap, 34 ventilators,64 high flow nasal oxygen, 43 non re-breathing mask and 58 non invasive ventilators), all outcomes are compared with same type of patients admitted in similar hospital and similar set of patients, without high dose vitamin c.

High dose vitamin-C in COVID-19 induced neuro-cognitive dysfunction

BACKGROUND: The current pandemic Covid-19 causes several clinical manifestations from asymptomatic presentation to more serious Severe Acute Respiratory Syndrome (SARS). There is no specific antiviral treatment for Covid-19 and the management is mainly symptomatic. The symptoms mainly include many neurological as well as cognitive impairment in majority of patients. AIM: The study aims to find out the covid induced neurological symptoms and cognitive dysfunction and the role of high-dose of oral liposomal vitamin C in patients admitted in Government Medical College & ESI Hospital, Coimbatore, India. MATERIAL: All the patients admitted with positive covid19 confirmed by RTPCR are randomly selected and included in study age between 18 years to-60 years only are included, male and female total number 150 are taken for study after getting informed consent. RESULTS: More than one Neurological Symptoms are experienced by 12-88% of patients and Cognitive Impairment by 82% of people. By Administrating Symptomatic treatments and supplements with 2 gms of liposomal Vitamin -C in a palatable juice form, 76% of them improved within 5 days rest of them in 10 days. CONCLUSION: Vit-c is most under estimated vitamin. It is cheap, easily available, more efficient and helps the body to fight against covid -19 too. High dose intravenous as well as oral liposomal vitamin-C is more effective in protection and recovery from covid -19 induced neuro-cognitive dysfunction.

Study of outcome of high dose oral liposomal vitamin-C in COVID-19 patients

Background: The current pandemic Covid-19 causes several clinical manifestations from asymptomatic presentation to more serious Severe Acute Respiratory Syndrome (SARS) on humans. There is no specific antiviral treatment for Covid-19 and the management is mainly symptomatic. Aim: To describe the role and outcome of high-dose of oral liposomal vitamin C treatment in a drink form for Covid-19 patients admitted in Government Medical College & ESI Hospital, Coimbatore, India. Materials and methods : Patients who admitted to the with the diagnosis of COVID-19 by RTPCR in government medical college and esi hospital Coimbatore during 15 th march 2020 to april 30,2020 are taken for study is one of the earliest cases studies of Covid-19 in the Indian subcontinent.

Prone position ventilation in COVID-19 ARDS patients- a prospective study

Introduction: SARS-CoV-2 virus causes a pneumonia that was identified through fever, dyspnoea, and acute respiratory symptoms and named COVID-19. This disease exacerbates in a number of patients and causes pulmonary edema, multi-organ failure, and acute respiratory distress syndrome (ARDS). Prevalence of ARDS among COVID-19 patients has been reported to be up to 17%. In the absence of effective targeted therapies for COVID-19, optimisation of supportive care is essential. micro vascular thrombi, Lung injury with features of acute respiratory distress syndrome (ARDS) appears to be the principal characteristic of severe acute respiratory syndrome corona virus 2 infection Among treatment methods for management of ARDS patients, prone position can be used as an adjuvant therapy for improving ventilation in these patients Aim : To find out the beneficial effects of prone position ventilation in COVID-19 patients ARDS. Presently, no published trials investigate the effectiveness of prone positioning in awake patients with typical ARDS Material and methods: Patients admitted in various tertiary care COVID-19 hospitals in coimbatore are taken for study. totally 300 patients on ventilators, invasive and non invasive ventilation are taken for study. Study period 1 st March 2020 to 28 th February 2021.